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Patients suffering from chronotropic incompetence are generally treated with a rate-responsive pacemaker that stimulates the heart at a rate derived from a strain related sensor signal. The pacemaker concept described here uses a well-defined time interval in the electrogram as sensor parameter (AVCT:  a trio- v entricular  c onduction  t ime). AVCT is directly controlled by the autonomic nervous system. The design of the new algorithm was based on a thorough experimental analysis of AVCT subject to variations of the exercise rate and the pacing frequency. There it was demonstrated that AVCT is disturbed by the respiratory activity. The new rate-responsive algorithm which uses the internal model control principle explicitly takes into account the closed-loop nature of the underlying system. The major design objectives were: a) extended range of the individual heart rate, b) effective attenuation of the respiratory related disturbance and c) dynamic stability. Seven patients undergoing an incre-mental exercise test were paced with the new AVCT-based algorithm. When paced with this algorithm the paced heart rate was 126±12 min -1  whereas the peak intrinsic heart rate was only 100±20 min -1 . The increase which was significant (26±13 min -1 ; 15..53 min -1 ) clearly demonstrated the potential of this concept to restore chronotropic competence. A reanalysis of the experiments was undertaken in order to facilitate the individual parameterization in clinical practice. It could be demonstrated that a rather simple screening test is sufficient to gain the knowledge necessary for the individual parameterisation.

The dromotropic pacemaker: System analysis and design considerations / Der dromotrope Schrittmacher: Systemanlyse und Entwurfskriterien