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Finding the location and morphology of subcortical structures in the human brain is of crucial importance for deep-brain-stimulation (DBS). DBS of the subthalamic nucleus (STN) is used as a treatment for Parkinson’s disease (PD) requiring accurate target positioning. However, segmenting the STN automatically is difficult because it is not clearly visible in magnetic resonance imaging (MRI). In this publication an improvement on the feasibility of an approach based on active shape models (ASM) for the automatic localisation of the STN is presented. Published: BMT 2012 – 46. DGBMT Jahrestagung, Jena (for internal use) 2

Improvements on the Feasibility of Active Shape Model-based Subthalamic Nucleus Segmentation