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High Sensitivity C-Reactive Protein (hsCRP) is an acute phase reactant synthesized primarily by liver after stimulation by various cytokines including IL-6 (Interleukin6). Hence, levels are elevated in various inflammatory diseases, including CKD (chronic kidney disease) especially in patients on hemodialysis [1]. IL-6 is a 26 kDa protein produced by the Kupffer cells of liver in response to inflammation. Its expression is regulated at gene expression level by interleukin-1 and tumor necrosis factor-α). Its levels are found to be elevated in CKD patients due to decreased clearance as well as increased production [2]. It is a strong inducer of CRP both in vitro and in vivo and its serum levels closely reflect CRP levels 2 . Hence, hsCRP and IL-6 are strongly correlated in most of the clinical conditions. In our study of 77 clinically diagnosed patients with CKD (Stage 3, 4 and 5) no correlation was seen between hsCRP and IL-6. The mean age (±SD) of patients with CKD was 49.6 (±14.0) years. The mean duration (±SD) of CKD was 20.6 (±18) months. The inflammatory parameters analyzed in this study were ESR (Erythrocyte Sedimentation Rate), hsCRP and IL-6 as shown in Table 1.

High Sensitivity C-Reactive Protein does not Correlate with IL-6 in Patients with Chronic Kidney Disease