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There is an increasing demand for novel antibiotics that are highly effective, but simultaneously reveal minimal side effects. Currently, major sources of antibiotics are found among bacterial genus  Streptomyces  and among fungal genera  Penicillium  and  Aspergillus. Chaetomium  represents the largest genus of the family Chaetomiaceae actually containing more than 100 described species. This rather complex genus has been reported as a rich source of secondary metabolite products with important biological activities, such as enzyme-inhibitory, antitumour, cytotoxic, antimalarial and also antibiotic effects. One of them, chaetomin, a part of  Chaetomium cochliodes  antimicrobial equipment was discovered already in the early period of antibiotics discovery, but later not investigated in sufficient detail. In this contribution we have studied  Chaetomium cochliodes  Palliser CCM F-232 for its possible antibacterial properties. For comparisons, a closely related fungus  Chaetomium globosum  was also employed. Antibacterial properties of  Chaetomium  sp. were tested on natural bacterial isolates of  Staphylococcus aureus  and  Bacillus subtilis . We performed several antimicrobial tests with a correlating output. Antibacterial effects of these filamentous fungi were demonstrated either by the presence of susceptibility zones on solid agar media in the case of  S. aureus  or by growth inhibition in liquid broth in the case of  Staphylococcus aureus  and  Bacillus subtilis .

biologia

Detection of the antibacterial effect of  Chaetomium cochliodes  Palliser CCM F-232 based on agar plugs and unprocessed fungal substances from cultivation media