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The pineal hormone melatonin plays an important role in immunomodulation of avian species. These im­munomodulatory effects of melatonin are known to be mediated by three membrane bound receptors found in birds, Mel 1a , Mel 1b  and Mel 1c - However, specific involvement of these receptors in mediating immunomodulatory effects of melatonin in Lung Associated Immune System (LAIS) remains unexplored till date. The aim of the present study was to check the specific melatonin receptor subtype involved in regulation of LAIS. For this purpose, we used luzindole, a non selective and 4P-PDOT, a selective Mel 1b  receptor antagonist under in vitro condition to assess their specific potency towards melatonin induced cellular immunity in the lung tissue of Perdicula asiatica. Melatonin enhanced proliferation of lymphocytes isolated from lung tissue and up-regulated both receptor types (Mel 1a  and Mel 1b ) on physiological doses while higher doses decreased the proliferation and down regulated the expression of both receptors. Luzindole decreased proliferation of lung lymphocytes and down-regulated the expression of both receptors in a dose dependent manner while 4P-PDOT decreased proliferation of lymphocytes isolated from lung and down-regulated the expression of Mel 1b  receptor subtype only. Proliferation rate of lymphocytes isolated from lung tissue followed more the expression pattern of Mel 1b  than the Mel 1a . Thus, we may suggest that Mel 1b  might be involved in cell mediated immunity in lung of P. asiatica to a greater extent than Mel 1a .

Me1 1b receptor mediated action of melatonin in regulation of lung associated immune system (LAIS) of Perdicula asiatica: An in vitro study