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Transforming RhoA proteins (RHOA) and their downstream Diaphanous homolog 1 proteins (DIAPH1) or mDia1 participate in the regulation of actin cytoskeleton which plays critical role in cells, i.e., morphologic changes and apoptosis.

RHOA and mDia1 promotes apoptosis of breast cancer cells via a high dose of doxorubicin treatment