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Production of IL-2 by CD4 +  T cells is shown to be suppressed in pregnant women infected by bacteria such as  Salmonella typhi. Elephantopus scaber  and  Sauropus androgynus  may be used as herbal supplement to ameliorate this condition. This study aimed to investigate the efficacy of  E. scaber  and  S. androgynus  formulation to promote lymphoid proliferation and CD4 cytokine productions. The pregnant mice were randomly divided into seven experimental groups: K- (control), K+ (with  S. typhi ), P1 ( S. typhi  +  E. scaber  100%), P2 ( S. typhi E. scaber  75% and  S. androgynus  25%), P3 ( S. typhi +  E. scaber  50% and  S. androgynus  50%), P4 ( S. typhi + scaber  25% and  S. androgynus  75%), and P5 ( S. typhi S. androgynus  100%). FACS analysis was done on day 18. Typhoid fever caused decreasing IL-2 and IFN-γ and in contrast increasing IL-4 production. In this experiment we clearly showed that typhoid fever decreased the amount of CD4 T cells but rather increased the amount of B cells. Formulation of  E. scaber  and  S. andogynus  was able to ameliorate the condition by increasing IL-2, IFN-γ, CD4 T cells and decreasing both IL-4 cytokine production and the amount of B cells.

open life sciences

Herbal supplement formula of   Elephantopus scaber  and  Sauropus androgynus  promotes IL-2 cytokine production of CD4 + T cells in pregnant mice with typhoid fever