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Multifunctionality can be achieved for bioactive glasses by endowing them with multiple other properties along with bioactivity. One way to address this topic is by doping these glasses with therapeutic metallic ions. In this work, we put under investigation a series of bioactive glasses doped with tantalum. We aim to study the effect of tantalum, on the structure, bioactivity and antibacterial property of a ternary bioactive glass composition based on SiO 2 -CaO-P 2 O 5 . Fourier Transformed Infrared Spectroscopy (FTIR), X-Ray Diffraction (XRD) and Electron Scanning Microscopy (SEM) were used to assess the structural and morphological properties of these glasses and monitor their changes after  in vitro  acellular bioactivity test. Antibacterial activity was tested against gram positive and negative bacteria. Characterization results confirmed the presence of calcium carbonate crystallites along with the amorphous silica matrix. The assessment of bioactivity in SBF indicated that all compositions showed a fast bioactive response after only six hours of immersion period. However, analytical characterization revealed that tantalum introduced a slight latency in hydroxyapatite deposition at higher concentrations (0.8-1 %mol). Antibacterial test showed that tantalum ions had an inhibition effect on the growth of  E. coli  and  S. aureus . This effect was more pronounced in compositions where mol% of tantalum is superior to 0.4%. These results proved that tantalum could be used, in intermediate proportions, as a promising multifunctional dopant element in bioactive glasses for bone regeneration applications.

Tantalum doped SiO 2 -CaO-P 2 O 5 based bioactive glasses: Investigation of in vitro bioactivity and antibacterial activities