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Depending on the species, position 5 in angiotensin II is occupied by isoleucine or valine. 1,8-disubstituted analogues of [Ile5]angiotensin II show distinct differences from the corresponding [Val5]angiotensin II analogues in the potency and specificity of their inhibitory action. The syntheses of new analogues are described.

1,8-Disubstituted Analogues of [Ile 5 ] and [Val 5 ]Angiotensin II: Difference in Potency and Specificity of Angiotensin II-Antagonistic Activity