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Parkinson's disease (PD) is a progressive neurodegenerative disorder in which oxidative stress is implicated as a major causative factor. Mutations in the gene encoding Parkin, a ubiquitin ligase, are responsible for a familial form of PD. In a  Drosophila  disease model lacking Parkin ( park   25   null mutant), we tested the effect of zinc supplementation. Zinc is an essential trace metal and a component of many enzymes and transcriptional regulators. Unlike copper and iron, zinc is not redox-active and under most conditions serves as an antioxidant. We find that the condition of  parkin  mutants raised on zinc-supplemented food is greatly improved. At zinc concentrations where controls begin to show adverse effects as a result of the metal supplement,  parkin  mutants perform best, as manifested in a higher frequency of reaching adulthood, extended lifespan and improved motoric abilities.

Zinc supplement greatly improves the condition of parkin mutant Drosophila