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Expression of the  KLK13  and  KLK14  genes was examined at the mRNA and protein levels in a cohort of 57 patients with non-small-cell lung cancer (NSCLC). The mRNA levels, assessed by real-time RT-PCR, were significantly different in malignant tissues compared to adjacent non-malignant tissues ( KLK13 ,  p =0.006;  KLK14 ,  p =0.022).  KLK13  and  KLK14  mRNA overexpression in tumors (1/3 of the patients) was associated with a positive nodal status in multivariate analysis ( p =0.018 and  p =0.069, respectively). KLK13 and KLK14 were localized in the cytoplasm of epithelial cells of normal bronchus and NSCLC, as determined by immunohistochemistry. Moreover, positive staining was significantly associated with adenocarcinoma histotype (KLK13,  p =0.014) and tumor size (KLK14,  p =0.048). Although the results are marginally significant, patients with high KLK13 expression at the mRNA or protein level had lower overall survival.

Quantitative RT-PCR analysis and immunohistochemical localization of the kallikrein-related peptidases 13 and 14 in lung