English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Open

Glucose-dependent insulinotropic polypeptide (GIP) is an incretin hormone secreted by endocrine K-cells in response to nutrient absorption. This study has utilised numerous well-characterised dipeptidyl peptidase IV-resistant GIP analogues to evaluate the glucagonotropic actions of GIP in Wistar rats and isolated rat islets. Intraperitoneal administration of GIP analogues (25 nmol/kg body weight) in combination with glucose had no effect on circulating glucagon concentrations compared to controls in Wistar rats. However, plasma glucose concentrations were significantly ( p &lt;0.05 to  p &lt;0.001) lowered by the GIP-receptor agonists,  N -AcGIP, GIP(Lys 37 )PAL and  N -AcGIP(Lys 37 )PAL. The GIP antagonist, (Pro 3 )GIP, caused a significant ( p &lt;0.05) reduction in glucagon levels following concurrent administration with saline in Wistar rats. In isolated rat islets native GIP induced a significant ( p &lt;0.01) enhancement of glucagon release at basal glucose concentrations, which was completely annulled by (Pro 3 )GIP. Furthermore, glucagon release in the presence of GLP-1, GIP(Lys 37 )PAL,  N -AcGIP(Lys 37 )PAL and (Pro 3 )GIP was significantly ( p &lt;0.05 to  p &lt;0.001) decreased compared to native GIP in isolated rat islets. These data indicate a modest effect of GIP on glucagon secretion from isolated rat islets, which was not observed  in vivo . However, the GIP agonists  N -AcGIP, GIP(Lys 37 )PAL and  N -AcGIP(Lys 37 )PAL had no effect on glucagon release demonstrating an improved therapeutic potential for the treatment of type 2 diabetes.

biological chemistry

Effects of gastric inhibitory polypeptide (GIP) and related analogues on glucagon release at normo- and hyperglycaemia in Wistar rats and isolated islets