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A new metabolite, 2,4-dihydroxyquinoline (DHQ), was identified in cultures of the bacteria  Pseudomonas aeruginosa  and  Burkholderia thailandensis . We found that the biosynthesis of DHQ correlates with the presence of a functional PqsA, which is a product of the  pqsABCDE  operon responsible for the synthesis of 4-hydroxy-2-alkylquinolines (HAQs) in  P. aeruginosa . However, DHQ is not a degradation product or precursor of HAQs. This finding sheds some light on the poorly understood biosynthesis pathway of HAQs, which includes important communication signals regulating the expression of virulence factors.

biological chemistry

PqsA is required for the biosynthesis of 2,4-dihydroxyquinoline (DHQ), a newly identified metabolite produced by  Pseudomonas aeruginosa  and  Burkholderia thailandensis