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The N-terminal propeptide domains of several cathepsin L-like cysteine proteases have been shown to possess potent inhibitory activity. Here we report the first kinetic characterisation of the inhibition properties of the cathepsin V propeptide (CatV PP). Using a facile recombinant approach we demonstrate expression, purification and evaluation of the CatV PP. This propeptide was found to behave as a tight-binding inhibitor against CatV ( K  i  10.2 n m ). It also functions as an inhibitor against other members of the CatL-like subclass (CatL, 9.8 n m ; CatS, 10.7 n m ; and CatK, 149 n m ) and had no discernible effects upon the more distantly related CatB.

Inhibition of cathepsin L-like proteases by cathepsin V propeptide