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Omp85 proteins form a ubiquitous protein family, members of which are found in all Gram-negative bacteria. Omp85 of  Neisseria meningitidis  and YaeT of  Escherichia coli  are shown to be essential for outer membrane biogenesis. Interestingly, there exists a homologue to YaeT in  E. coli  and many proteobacteria, denoted YtfM, the function of which has not been described yet. Like YaeT, YtfM is predicted to consist of an amino-terminal periplasmic domain and a membrane-located carboxy-terminal domain. In this study, we present a first characterisation of YtfM by comparison to YaeT concerning structural, biochemical and electrophysiological properties. Furthermore, a knockout strain revealed that  ytfM  is a non-essential gene and lack of the protein had no effect on outer membrane composition and integrity. The only observable phenotype was strongly reduced growth, indicating an important role of YtfM  in vivo .

Characterisation of YtfM, a second member of the Omp85 family in Escherichia coli