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To support the study of kinin pharmacology in bovine models of cultured endothelial cells (ECs), the Bovine Genome Project was searched for a B 1  receptor (B 1 R) gene ortholog ( BDKRB1 ). A contig complementary to an intronless coding nucleotide sequence was found. The sequence was amplified from bovine EC DNA, further cloned into pcDNA3 and expressed in COS-1 cells. The bovine B 1 R sequence was confirmed and extended. A putative Zn 2+ -binding motif HEXXH is not present (replaced by HDAWP). The receptor binds [ 3 H]Lys-des-Arg 9 -bradykinin in a saturable manner ( K  d  0.36 nM) and exhibits a pharmacological profile similar to that of human B 1 R.

Molecular identification and pharmacological profile of the bovine kinin B 1 receptor