English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

In contrast to the wellknown regulation of cytochromeP450 (CYP) activity by enzyme induction, which represents a process with slowonset and slow offset, more recent studies revealed phosphorylation as a fast(within observation instantaneous) and isoenzymeselective regulation. Thephosphorylated enzyme (investigated isozyme: CYP2B1) was fully inactive. Thephosphorylation is mediated by PKA and hence under control of hormones anddrugs that alter cellular cAMP levels. The consequences for the metaboliccontrol of toxic species derived from drugs and environmental carcinogens arediscussed. This information will help to improve therapy with drugs metabolizedby CYPs which are phosphorylated by PKA, especially if these drugs possess anarrow window between required effectiveness and unacceptable toxicity.

Fast Regulation of Cytochrome P450 Activities by Phosphorylation and Consequences for Drug Metabolism and Toxicity