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Nitric oxide (NO) is synthesised by different nitricoxide synthases (NOS) from Larginine and acts as a signal transducer in avariety of cells. The neuronal isoenzyme of NOS (nNOS) was recently found inrodent βcells and βcell lines. We provide evidence that nNOS is also present inthe human βcell line CM and that the specific inhibitor of nNOS PIN isexpressed in CM and INS-1 cells. Furthermore, we investigated the influence ofglucose on the activity of nNOS and the expression of PIN and are able to showthat both are increased by glucose stimulation in the βcell lines but not inthe mouse fibroblastic cell line LTK. This indicates that nNOS and PIN play arole in the specific function of βcells, not only in rodents but also inhumans.

Neuronal NO Synthase and Its Inhibitor PIN Are Present and Influenced by Glucose in the Human β-Cell Line CM and in Rat INS-1 Cells