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A synthetic peptide corresponding to the amino acid sequence Arg 1487 -Arg-Gly-Arg-Thr-Gly-Arg-Gly-Arg-Arg-Gly-Ile-Tyr-Arg 1500  of the hepatitis C virus (HCV) polyprotein was found to be a selective substrate for protein kinase C (PKC). In the presence of Ca 2+ , TPA and phospholipid, PKC phosphorylates the peptide [termed HCV(1487–1500)] with a  K  m  of 11μM and  V  max  of 24 μmol × min −1  × mg −1 . HCV(1487–1500) acts as a competitive inhibitor of PKC towards other peptide or protein substrates and inhibits the kinase activity with an IC 50  corresponding to the  K  m  values measured for the substrates. N- or C-terminally deleted analogs of HCV(1487–1500) did not show inhibitory effects and were only marginally or not phosphorylatable.

A Synthetic Peptide Derived from the Non-Structural Protein 3 of Hepatitis C Virus Serves as a Specific Substrate for PKC