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Genetic experiments in the yeast  Saccharomyces cerevisiae  have identified the five Not proteins as global repressors of transcription which preferentially repress core promoters which do not contain a canonical TATA sequence. Recently, the Ccr4 and Caf1 proteins, required for non-fermentative gene expression, were found to be associated with the five Not proteins in 1.2 and 2 MDa Ccr4-Not complexes. These Ccr4-Not complexes, as many other global regulators of transcription, appear to regulate transcription both positively and negatively  in vivo .

In Vitro Transcription of a TATA-Less Promoter: Negative Regulation by the Not1 Protein