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This study was designed to examine the antioxidant defense by chloroform extract of Calotropis gigantea on streptozotocin-(40mg/kg, intraperitonial, single-injection) induced diabetes in wistar albino rats. The extract significantly (P &lt; .05) decreased the pancreatic thiobarbituric acid-reactive substances (TBARS) levels and significantly (P &lt; .05) increased the superoxide dismutase, catalase, and glutathione levels as compared to above levels in pancreatic tissue of pathogenic diabetic rats. The results of test drug were comparable to Glibenclamide (5mg/kg, daily), a standard antihyperglycemic agent. The study concludes that Calotropis gigantea enhances the antioxidant defense against reactive oxygen species produced under hyperglycemic condition and this protects β-cells against loss, and exhibit antidiabetic property.

Antioxidant Potential and Protection of Pancreatic ?- cells by Calotropis gigantea in Streptozocin Induced Diabetic Rats