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Late reoperation for proximal aortic and arch complications after previous composite graft replacement in Marfan patients. An aortic valve-sparing operation for patients with aortic incompetence and aneurysm of the ascending aorta. root surgery in Marfan syndrome: comparison of aortic valve-sparing reimplantation versus composite grafting. We would like to congratulate Okamoto and colleagues for their interesting report w1x. Their case illustrates again how difficult it is to treat and manage patients with Marfan syndrome before and even after several aortic (root) surgeries. Ostial aneurysm formation is a well known complication after aortic root surgery in Marfan syndrome w2x. We agree that it is crucial to excise as much aortic root tissue as possible when re-implanting the coronary arteries in the Dacron graft. We use felt or pericardial patches to strengthen the suture-line around the ostium and to prevent future aneurysm formation at this area. Unfortunately, progressive aortic dilatation can sometimes not be prevented, and it is clear that aneurysm formation of the left trunk itself cannot be prevented by a small, reinforced button technique alone. Interestingly, it has recently been shown that losartan, an angiotensin II type 1 receptor blocker, and widely used medication to treat arterial hypertension, has the potential to stabilize the aortic root tissue in Marfan syndrome w3, 4x. Brooke and colleagues recently published from Johns Hopkins a small pediatric cohort study in which the use of angiotensin II type 1 receptor blocker therapy in patients with Marfan syndrome slowed the rate of progressive aortic root dilatation from 3.54"2.87 mm per year during previous medical therapy to 0.46"0.62 mm per year during angio-tensin II type 1 receptor blocker therapy (P-0.001) w5x. These findings are incredibly encouraging for patients with Marfan syndrome , and we think that it might, therefore, be time to start patients with Marfan syndrome – before and after aortic root surgery – on losartan therapy. However, whether angiotensin II type 1 receptor blocker therapy is effective in preventing ostial and coronary dilatation after aortic root surgery in Marfan syndrome requires, of course, further studies. Angiotensin II blockade and aortic-root dilation in Marfan's syndrome. One of the typical problems in the long follow-up period after a classic Bentall operation is the formation of coronary ostial aneurysm. According to data of various authors the frequency of this complication achieves 8.5%. At the same time, messages on formation of coronary ostial aneurysm, when performing the modified Bentall technique, …

eComment: Stabilizing aortic tissue after aortic root surgery in Marfan syndrome