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Chromosomal relationship between humans and dusky langurs (Trachypithecus obscurus, 2n=44) was established by chromosome painting using chromosome specific DNA probes of the human chromosome 1 and 19 which each gave hybridization signals on two non-homologous dusky langur chromosomes. The results show that the human chromosome 1 and 19 probes hybridized to three regions of dusky langur on the autosomes 6 and 8. The human chromosome 1 probe hybridized to one region on the dusky langur chromosome 6 and two regions on the dusky langur chromosome 8, where the human chromosome 19 probe hybridized with the same pattern but on different regions. Hybridization patterns of human painting probes on dusky langur, when compared with the data of other species in the same genus suggest that the alternating hybridization pattern of the conserved segments homologous to human chromosomes 1 and 19 on dusky langur chromosomes 6 and 8 is the result of the translocation followed by the pericentric inversion. Moreover, the present research also indicates that the dusky langur's chromosomes 6 and 8 have the same hybridization patterns as other Asian colobines.

cytologia

The Homology and Relationship of Human (Homo sapiens) Chromosomes 1, 19 and Dusky Langur (Trachypithacus obscurus) Chromosomes 6, 8 Demonstrated with Chromosome Painting