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The action of MHQD on a meristematic root cell population of Allium sativum L. has been studied in order to investigate the possibility of using MHQD as a morphological labeller and to specify the advantages and disadvantages of the method.After a brief treatment, MHQD causes the immediate appearance of binucleate cells. These cells have normal kinetic parameters and there is no significant loss of synchronism between their two nuclei. This sample of labelled cell population goes synchronously throughout the cell cycle. Unlike caffeine, MHQD does not modify the mitosis duration nor the DNA synthesis ratio. Therefore, MHQD seems suitable as a morphological labeller, useful for the study of the action of various cell cycle inhibitors. Two examples of application of this method are given in order to outline its interest.

Methyl-3 hydroxy-6 quinazoline dione-2-4, a new compound for labelling plant cells. Application to the study of two inhibitors of cytokinesis.