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Papaverine hydroehloride, which is an aak.~doid l'ound in opium, induced c-metaphase, c-anaphaso, n0n-congreasion, diagonal anaphase, chromosome and chromatid bridges, lagging of chromosomes, micronuclei and muitinueleated ceils in root tips os All lum cepa. I t is tim only one amongst the alkaloids of opium which caused a high increase in MI after a long period of treatment with some low concentrations. In a p r e v i o u s r e p o r t b y K A B A R I T r et al. I 9 7 4 t h e c y t o l o g i c a l e f f e c t o f m o r p h i n e s u l p h a t e , w h i c h is a n a l k a l o i d f o u n d p r i n c i p a l l y i n o p i u m , w a s d i s c u s s e d . T h e p r e s e n t s t u d y d e a l s w i t h t h e c y t o l o g i c a l e f f e c t o f p a p a v e r i n e T ~ 1 Mitotic index (MI) and prophaae]motupha~ ratio (P/M) after tre~t.ing Agium eepa roots with Treat Cone. 4 h I2 h • 10 .6 mot m1-1 TotaI Total ceils MI P/M ceils MI pJM examlnod examined 6.6 11 414 2.I0 0.50 : 1 * 3.3 10 514 3 .35 0 , 8 0 : 1 * 1 .66 1 0 5 4 2 2 . 8 6 1 ,13 : 1 12 719 8 .82 3 . 3 9 : 1 0 . 8 3 12 017 2 .36 2 . 9 2 : 1 13 151 2,81 1.52 : 1 0.42 9 505 3 .72 2 . 6 4 : I 13 046 6.14 1.17 : i 0.21 13 8fil 4.55 2,80 : 1 13 913 6,72 1.06 : 1 0.1O 11 999 5.62 2.08 : 1 12 343 4.04 0.94 : 1 0.00 12 729 5.88 2.09 : I 9 977 5.64 2.01 : 1

Cytological effects of papaverine hydrochloride on root tips of Allium cepa L.