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Activities of some potent synthetic adrenocorticoids and the original ones were compared by a new scoring method based upon the change in intravenous glucose tolerance curve in rat. 9α-FHC was the most potent, followed by Δ1-9α-FHC, Δ1-C, Δ1-HC, HC and C, but without significant difference between the first and the second, and the fourth and the fifth of them.The method is expected to be useful for the estimation of glucocorticoid activity.

COMPARISON OF GLUCOCORTICOID ACTIVITY OF SOME SYNTHETIC ADRENOCORTICOIDS BY A NEW METHOD BASED UPON INTRAVENOUS GLUCOSE TOLERANCE CURVE IN RAT