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The in vitro degradation of I131-labeled Parotin as well as similarly labeled bovine serum albumin, pituitary growth hormone, and casein by several tissue homogenates of rat, was studied by measuring the increase of the radioactivity in the non-protein fraction of the incubation mixture and also by employing the quantitative paperchromatographic analysis.I131-labeled Parotin, growth hormone and casein were degraded with remarkable rapidity by submaxillary gland homogenate.And some appreciable degradation of these three radioiodinated proteins was observed in case of kidney, spleen, parotid gland, muscle, testis, liver and pancreas homogenates. By paperchromatographic analysis, the degradation of the labeled proteins by submaxillary gland homogenate and other tissue homogenates was not found to be deiodination but presumably proteolytic degradation.

endocrinologia japonica

STUDIES ON THE SALIVARY GLAND HORMONES LABELED WITH I&lt;SUP&gt;131&lt;/SUP&gt;4. STUDIES ON THE DEGRADATION OF I&lt;SUP&gt;131&lt;/SUP&gt;-LABELED PAROTIN BY SEVERAL TISSUE HOMOGENATES OF RAT