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Effects of growth hormone and cortisone acetate upon mitotic activity in amphibian tissues were studied.Following daily administrations of growth hormone in the doses of 2-400γ in total, mitotic stimulation was demonstrated in the regenerating and normal epidermis in the four post-operative day. Also temporal stimulation of mitotic activity was demonstrated in the larval bull frogs six days after injection of the daily dose of 25γ attended with subsequent reduction in activity.Inhibition of mitotic activity was the case in the epidermis of the normal and the regenerating limb when four consecutive daily injections of cortisone acetate in the dose of 4mg in total were received subcutaneously. But no significant effects could be demonstrated on the mitotic activity of the regenerating epidermis of the adult newt following administration of lower dosage levels of 0.05-2mg in total.After the inspection of mitosis-rate in the epidermis, replacing cells of the small intestine and cortical parts of the liver of the adult newt received growth hormone and cortisone acetate in the dosage level of 400γ and 4mg in total respectively, only epidermal cells were responsive to the administration of the hormones.

EFFECT OF GROWTH HORMONE AND CORTISONE ACETATE UPON MITOTIC ACTIVITY IN NORMAL AND REGENERATING TISSUES OF AMPHIBIA