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1. Insulin-urinary sugar equivalent for one unit of insulin was found as 5.5gm of glucose in alloxan dog and as 2.8gm glucose in pancreatectomized dog. The daily dosage of insulin requirement was calculated as 23.4 units for alloxan diabetic and 11.6 units for pancreatectomized dog.2. The fasting blood sugar level of pancreatectomized dog showed definitely high sensitivity to the action of insulin, but no sensitivity was demonstrated in alloxan diabetic dog.3. The levels of blood sugar and glycosuria were elevated and the higher insulin dosage was required when ACTH or cortisone was administered, but the less dosage of insulin was required in the case of DOC. Also it was clarified that, under the experimental condition, ACTH and cortisone have a contrainsulin effect and DOC showed an insulin effect.4. The elevated blood sugar level by the daily administration of ACTH and cortisone continued its high level for over 7 days from the time of withdrawal of the hormones in alloxan diabetic dogs, while blood sugar value was lowered immediately after the withdrawal of the hormones in pancreatectomized dogs, though concerning glycosuria, there was no difference noted between the two types of diabetes.5. Signiffiant difference was found that the fasting blood sugar level in alloxan diabetic dog was indifferent to insulin treatment, and the effect of ACTH and cortisone remained long when the administration of these hormones was stopped in alloxan diabetic dog, suggesting the enhanced production of contrainsulin in the endocrine system in alloxan diabetic dog.

endocrinologia japonica

COMPARATIVE STUDIES OF ALLOXAN DIABETIC DOG AND PANCREATECTOMIZED DIABETIC DOG ON THE REGULATION OF THE CARBOHYDRATE METABOLISM WITH SPECIAL REFERENCE TO THE ACTION OF ACTH AND ADRENOCORTICAL HORMONES ON THE INSULIN REQUIREMENT