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Phases of mitotic activity and some of the histologic features in the regenerating tissues of the forelimb and of the dorsal skin were observed for 29days after partial destruction of the organs in question in both normal and hypophyscctomized adult newts. Two consecutive phases of mitotic activity were learned to take place in regenerating process of the limb-tissues. The one progresses in the epidermis in the early period of regeneration, and the other in the mesodermal tissues in the period succeeding the days of epidermal proliferation. Hypophysectomy was found to inhibit both of the mitotic activities in the regenerating limbs and the epidermal activity in the healing dorsal skin significantly.

EFFECT OF HYPOPHYSECTOMY UPON MITOTIC PROLIFERATION IN REGENERATING TISSUES OF THE ADULT NEWT