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We have examined the binding of 44% saponin from Panax ginseng, and extracts from Eluthrococcus senticosus (Siberian ginseng) to classical steroid receptors in vitro. Both extracts had demonstrable affinity for progestin, mineralocorticoid and glucocorticoid receptors; the Siberian ginseng also bound to estrogen receptors. Highest affinity binding was to glucocorticoid receptors, with an approximate Ki of 8 x 10(-6) M for Panax ginseng. Such interactions may explain the reported glucocorticoid-like effects of ginseng in vivo.

Panax ginseng and Eleuthrococcus senticosus extracts - in vitro studies on binding to steroid receptors.