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Concentrations of arginine-vasopressin (AVP) in the cerebrospinal fluid (CSF) of 5 alcoholic patients and 6 healthy volunteers were determined by a radioimmunoassay. The concentrations of AVP in the CSF of alcoholic patients were 2.93-6.17 pg/ml (the mean value, 4.80 +/- 1.34 pg/ml) and those of healthy volunteers 3.80-12.59 pg/ml (the mean value, 9.87 +/- 3.19 pg/ml). The AVP level in the CSF of alcoholics was significantly lower than that of normals (P less than 0.02).

The levels of vasopressin in cerebrospinal fluid of patients with alcoholism.