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Under constant experimental conditions of room temperature and illumination, a highly significant seasonal difference was observed in the mortality rate of rats which received hydrocortisone on the first day of life. The rate was high in winter and low in summer. Inborn circannual variation of the susceptibility to exogenous corticosteroid was shown to exist in newborn rats.

Circannual variation of mortality rate following a single injection of hydrocortisone in newborn rats.