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The effect of calcitonin (CT) on the serum and liver calcium is examined in rats ligated the bile duct. The subcutaneous administration of CT (80 MCR mU/100 g BW) significantly prevented the increase of serum calcium concentration after a single oral injection of calcium (50 mg/100 g BW) to sham-operated rats. But the ligation of bile duct prevented the hypocalcemic effect of CT. Meanwhile, CT significantly increased the liver calcium content after the calcium injection to sham-operated rats. However, the liver calcium content after CT administration was markedly elevated by the ligation of bile duct in comparison with that of sham-operated rats. The present results suggest that the liver calcium increased by CT administration secretes into the bile.

Effect of calcitonin on calcium concentration in serum and liver of rats ligated bile duct.