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In four patients with euthyroid Graves' disease, serum T3 concentration and TRH response were tested. All four patients showed T3 concentration within normal range, albeit representing TRH-refractoriness. The results suggest the possibility that thyroid hormone concentration is not a sole determinant of TRH-responsiveness in Graves' disease, implying currently undetermined pathologic process underlying the abnormality.

Normal Serum Triiodothyronine Concentration and the Lack of TSH Response to TRH in Patients with Euthyroid Graves' disease