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β-alanine orα-aminoisobutyric acid(Ibu) and protection of the C-terminal carboxyl group by amide formation enhanced the anti-diuretic action. Purified TSH, LH, FSH, GH, and prolactin probably inert under the experimental condition. Similar biphasic effect of the Ibu1-ACTH(1-18)-amide was also observed in hypophysectomized or adrenalectomized rats with almost the same potency as that in nonoperated rats. Weak anti-diuretic action of Ibu1-ACTH(1-18)-amide was also demonstrated in water-loaded intact rats.

Effects of ACTH and its Synthetic Analogues on Water Balance in Rats