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In addition to the cytoplasmic secretory activity in the cells of the preoptic nucleus of the eel, Anguilla japonica, which is responsible for the production of the so-called Gomori-positive neurosecretory material, a characteristic secretory activity is disclosed with the nuclei of the cells in question. Various aspects of nuclear transformation are observed, which are regarded to be concerned with the elaboration of a kind of acidophil, Gomori-negative, secretory material. The secretory material is conceded to be produced as the result of a kind of pyknotic change of the cell nucleus, and partially extruded into the blood capillaries without being subjected to further transformation within the cytoplasm. The modified ncleus presumably restores its integrity through a process of differentiation of basophil elements from the remainder of the acidophil material. Such nuclear change is not associated with any visible sign of cellular degeneration, and are considered to be of characteristic features in physiologically normal animal.

STUDIES IN NEUROSECRETION III. NUCLEAR SECRETION IN THE CELLS OF THE PREOPTIC NUCLEUS IN THE EEL (ANGUILLA JAPONICA)