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Intraperitonael administration of 0.1 to 0.2gm/kg Na-Sulfacetylthiazole (SAT) twice a week for 4 weeks induced obstructive nephropathy, and bone changes similar to osteoporosis with a decrease in the X-ray density and calcium content of the tail bone and femur, decrease of femoral cortical thickness and an increase in bone resorption cavities in 3 month old rats. Such bone changes, prevented through prior parathyroidectomy, might be due to increased parathyroid hormone activity secondary to SAT-induced renal injury.

Effect of Parathyroidectomy on Bone Atrophy Induced by Renal Injury with Na-Sulfacetylthiazole