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Measurements of insulin-like growth factor-I (IGF-I) are useful not only for diagnosis and management of patients with growth hormone (GH)-related disorders but also for assessing nutritional status.  We reported population-based references of serum IGF-I in 1996.  However, they did not properly reflect data in the transition period from puberty to maturity.  The aim of the present study was to re-establish a set of normative data for IGF-I for the Japanese population.  The study included 1,685 healthy Japanese subjects (845 males, 840 females) from 0 to 83 years old.  Subjects suffering from diseases that could affect IGF-I levels were excluded.  Obese or extremely thin adult subjects were also excluded.  IGF-I concentrations were determined by commercially available immunoradiometric assays.  The reference intervals were calculated using the LMS method.  Median IGF-I levels reached 310 ng/mL in males at the age of 14 years and 349 ng/mL in females at the age of 13 years, falling to 124 ng/mL and 103 ng/mL, respectively, by the age of 70 years.  The mean pretreatment IGF-1 SD scores in patients with severe GH deficiency (GHD) obtained from the database of the Foundation for Growth Science and from clinical studies for adult GHD were -2.1±1.6 and -4.9±2.5, respectively.  The present study established age- and gender-specific normative IGF-I data for the Japanese population and showed the utility of these references for screening patients with severe GHD.

endocrine journal

Standardized centile curves and reference intervals of serum insulin-like growth factor-I (IGF-I) levels in a normal Japanese population using the LMS method