English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

adaptive responses in anticipation of a future poor nutritional environment, modifying its metabolism to become a thrifty phenotype, only to discover it has been born into an environment of nutritional excess. Such a predictive adaptation in utero which is mismatched with its later improved environment is thought to put the fetus at risk of developing obesity, type 2 diabetes, and other adult diseases in later life when it is exposed to high fat diet and insufficient physical exercise in modern lifestyle. Such a fetal response is named ‘predictive adaptive responses.’ Predictive adaptive responses are phenotypic modulations with altered gene transcription. Gene transcription during fetal period is affected by various stimuli including maternal nutrition, hypoxia, oxygen stress, etc. Such a modulation of gene transcription is mediated through alteration of expression of transcription factors which regulate multiple steps of organogenesis and establishing metabolic functions. These changes in multiple gene expressions ultimately result in phenotypic alteration and disease susceptibility. The mechanism by which transcription is regulated without alteration of DNA sequence during development in utero is postulated to be through epigenetic regulation, which determines the timing and intensity of expression of specific genes by modulating chromatin conformation. The chromatin conformation can be modified mainly through methylation or demethylation of the cytosine base in CpG island of DNA, and acetylation or deacetylation of the amino termini of histones.

Maternal nutrition and long-term consequences of the offspring