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GH acts on not only skeletal growth, but also various metabolisms such as anabolism, lipid and electrolytes, and the immune system. The actions of GH are mediated through binding to specific receptors located on cell membranes. The specific receptors for GH have been identified in various tissues such as hepatocytes, cartilage and adipocytes [1-3]. Circulating lymphoid cells as well as lymphoid-derived cell lines also express both GH receptors (GHR) and insulin like growth factor (IGF)-I receptors [4, 5]. Clinical studies with peripheral lymphocytes from relatively small blood collections are useful for evaluating GHR status as tissue biopsies are not required. Studies on the binding of GH to human peripheral lymphocytes have been carried out but little is known about the regulation of GHR in the lymphocytes because there is little binding. The recent development of RTPCR makes it be possible to measure the expression of mRNA with a small amount of RNA. Therefore, in the present study, we measured GHR mRNA levels in the lymphocytes from patients with GH deficiency (GHD) and acromegaly by using quantitative RT-PCR, and investigated whether the circulating GH and/or IGF-I affects the levels of GHR mRNA. We also measured the receptor mRNA levels of IGF-I, that mediates many effects of GH in endocrine, paracrine and autocrine fashion.

Growth Hormone (GH) Receptor and IGF-I Receptor Messenger RNA Expression in Peripheral Lymphocytes from Patients with GH Deficiency and Acromegaly