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GH is involved in growth and development in vertebrates [1]. The actions of GH are initiated by its binding to the specific GH-receptors (GH-R) localized in the cell membrane of target tissues [2]. GH also binds to a soluble GH-binding protein (GH-BP) in serum [3]. The GH-BP is generated from a variant mRNA resulting from an alternative splicing of GH-R mRNA precursor at the exon 7-8 boundary [4]. It has been reported that the expression of GH-R and GH-BP mRNAs increases in pregnant mouse liver, and it decreases gradually in the mammary

Tissue-Specific Regulation of Growth Hormone Receptor and Growth Hormone Binding Protein Gene Expression during Pregnancy and Lactation in the Rat