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The clearance and production rates of plasma angiotensinogen of normal dog, nephrectomized dog and angiotensin converting enzyme inhibitor (ACEI) administered dog were calculated. Plasma angiotensinogen was measured by adding excessive dog renin to the plasma sample. The clearance rate was 4.4, 4.0 and 3.8 ml/kg/hr and the production rate was 9.6, 21.6 and 7.6 micrograms/kg/hr, respectively. After nephrectomy, the clearance rate of angiotensinogen decreased only 10 percent but the production rate increased more than twice. These results mean that the kidney does not play an important role in the clearance of angiotensinogen but has some influence on its production. This increase in production rate due to nephrectomy may mean that the kidney has some inhibitory effect on the secretion of angiotensinogen from the liver but this phenomenon is not able to explain by much less hydrolysis of angiotensinogen. By the administration of ACEI, not only the clearance rate but also the production rate of plasma angiotensinogen decreased as compared with control dog, but the balance between them resulted in the decreased plasma angiotensinogen concentration. These results show that the decreased production rate was greater than the decreased clearance rate in ACEI administered dog.

The Effects of Nephrectomy and Angiotensin Converting Enzyme Inhibitor on Production and Clearance rates of Antiotensinogen in Dogs