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I measured urinary hGH level in children with insulin dependent diabetes mellitus (DM) and studied the relation with urinary albumin alpha 1-microglobulin (alpha 1 MG), beta 2-microglobulin (beta 2MG) and plasma HbA1. 24-hour urine or night-time urine was collected in 54 normal children (NC) and 61 DM. Urinary hGH was estimated by using a sensitive sandwich enzyme immunoassay. Urinary albumin, alpha 1 MG and beta 2MG were measured by RIA. HGH concentration in 24-hour urine in NC significantly correlated with urinary albumin and beta 2MG concentrations (p less than 0.01). In DM, hGH concentration in 24-hour urine also correlated with urinary albumin concentration (p less than 0.05). To avoid the effects of posture and exercise, night-time urine was used in the following study. Urinary hGH concentration was significantly higher in DM for all age (p less than 0.05-0.01) than that in NC. Urinary alpha 1MG and beta 2MG concentrations were also significantly higher in DM than those in NC. HGH concentration in night-time urine in NC has not correlated with urinary albumin, alpha 1MG nor beta 2MG. In DM, however hGH significantly correlated with urinary albumin and beta 2MG. Even in DM with normal concentrations of urinary albumin and beta 2MG, urinary hGH was significantly higher than in NC. Urinary hGH in poorly controlled DM was higher than in well controlled DM. Urinary hGH concentration showed positive correlation with plasma HbA1 in DM. We conclude that urinary hGH relates to not only serum hGH concentration but also renal function. In DM with normal renal function, hGH concentration in night-time urine was higher than in NC, which suggested high serum hGH concentration in DM.

Urinary hGH, Albumin, α<SUB>1</SUB> MG and β<SUB>2</SUB> MG in Normal and Diabetic Children