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There have been few reports about the concentrations of plasma cAMP and cGMP in patients with hyperand hypothyroidism. The aim of this study is to discribe the concentrations of these plasma nucleotides and to discuss the relationship between plasma nucleotide levels and the concentrations of serum thyroid hormones and TSH in these patients. Four hundreds and eleven serum samples were obtained from 307 outpatients, 137 of them were from patients with Graves' disease and the rest from chronic thyroiditis. The patients with Graves' disease were divided into four groups; 19 samples from untreated patients (group I), 37 from treated patients with still elevated thyroid hormone levels (group II), 64 from treated patients with normal thyroid hormone levels (group III), and 17 from

Plasma cAMP and cGMP Concentrations in Outpatients with Graves' Disease and Chronic Thyroiditis