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Adrenal androgen is thought to take part in the expression of secondary sexual characteristics and growth spurt with the onset of puberty. Its secretion is known to rise prior to the increase of gonadotropin and gestagen secretion in the pubertal period. But there are many unsolved problems concerning its physiological activity and the regulation of its secretion. To investigate these problems, we measured serum dehydroepiandrosterone sulfate (DHEA-S) in normal children and 41 patients with pituitary dwarfism and analyzed the relation of serum DHEA-S levels to puberty, growth and pituitary function. Serum DHEA-S was measured by RIA modified by Buster's method. Serum DHEA-S levels of normal children started to rise after 6 years of age, and rapidly increased over 9

The Study of Serum Dehydroepiandrosterone Sulfate Levels in Normal Children and Children with Pituitary Dwarfism