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Recently, the predominant molecular forms of cholecystokinin (CCK) in extracts of tissues from the central nervous system and small intestines of adult man and hog have been demonstrated to correspond to the COOH-terminal octaand tetra-peptide of CCK. CCK is one of the established gastro-intestinal hormones capable of stimulating pancreatic exocrine secretion. In addition, pure natural porcine CCK, synthetic COOH-terminal octa-peptide of CCK and synthetic caerulein which contains a COOH-terminal penta-peptide identical to CCK have been shown to stimulate insulin and glucagon secretion in vivo and in vitro. Thus, it seems reasonable to expect some effect of these COOH-terminal fragments of CCK on pancreatic exocrine and endocrine secretion. The present study was, therefore, undertaken to compare the various COOH-terminal fragments of CCK with those effects on pancreatic exocrine and endocrine secretion in the rat. Pancreases from male Wistar rats, fed ad libitum, were isolated according to the technique of Kanno. Perfusate consisted of a Krebs Ringer bicarbonate buffer containing 4.6% Dextran T-70 and 0.25% bovine serum albumin. The effects of various COOH-terminal peptides of CCK (synthetized by Prof. Noboru Yanaihara, Shizuoka) at the doses ranging from 10-II to 10-8M were studied in the presence of 50mg/d1 or 150mg/d1 glucose. Insulin (IRI) and glucagon (IRG) levels in the portal effluent were determined by radioimmunoassay using polyethyleneglycol and charcoaled dextran with antiserum 30K, respectively. Amylase activities in the pancreatic juice were assayed by a chromogenic method with blue-dyed starch polymer.

The Effect of COOH-terminal Peptides of Cholecystokinin on the Exocrine and Endocrine Pancreas in the Rat