English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

It has been established that hypoglycemia stimulates the secretion of human growth hormone (HGH) from the pituitary gland. If the secretion ofendogenous insulin from the pancreatic-cells was temporally increased by tolbutamide i.v. injection and hypoglycemia was produced, the serum HGH would be increased as well as the insulin-induced hypoglycemia. In the present study, 1 g tolbutamide was injected i.v. into normal subjects, hyperthyroidism, primary or secondary hypothyroidism, diabetes mellitus and into nephrotic syndromes with or without adrenocortico-steroid hormones in order to know some of the aspects of the mechanism concerning the secretion of HGH from the pituitary gland under hypoglycemia. In the normal subject, maximum response of serum IRI (Immunoreactive Insulin) was seen within 15 min and the lowest value of blood sugar (50 mg/100 ml) was observed at 30-45 min after the injection of tolbutamide. The serum HGH was clearly increased at 15 min, the highest value of HGH (approximately 15 ng/ml) was achieved 60 min after the I.V. administration of tolbutamide and then the value declined to the fasting level, i.e. around 5 ng/rnl. The response-patterns of serum IRI and blood sugar to tolbutamide injection in the patient with hyperthyroidism and primary or secondary hypothyroidism were similar, but HGH showed quite different patterns. Although maximum increase of HGH was slightly lower than that of normal subject, the HGH value was still high even 3 hrs after tolbutamide injection in cases of hyperthyroidism. In primary hypothyroidism, the pattern of response of HGH secretion by the tolbutamide test was clearly impaired, compared with normal subjects. These results suggested that thyroid hormones would be necessary for production and secretion of HGH. No response of HGH was

nippon naibunpi gakkai zasshi/nihon naibunpi gakkai zasshi/naibunpigaku zasshi

Growth Hormone Secretion from the Pituitary after a Single Dose of Tolbutamide Injection in Normal Subject, Hyperthyroidism, Hypothyroidism, Diabetes Mellitus and Nephrotic Syndromes