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1) Doses of 0.5 mg. of carrier "'I and 131I were given by mouth to 6 subjects, and 131 uptake rates and 131I discharge values were examined . The mean 3 hr uptake rate was 4.35±1.35%, and the mean 'I discharge value after perchlorate administration was 一6 .75土15.41%.Anegativedischargcof1311fromthyroidswasshown. 2) In 5 subjects who received 2.0 mg. of carrier 'I and "'I tracer, the perchlorate discharge tests were also negative, the mean "'I discharge value was .7.58+4.30%. 3) 5 subjects were pretreated with 10 mg. of mercaptoimidazol per day for 3 days. Thereafter, perchlorate discharge tests were carried out without carrier "'I administration. The mean "'I discharge value was 3.63+6.35% and "'I discharge in the tests was negative. 4) Doses of 0.5 mg. of carrier "'I and "'I were given to 4 subjects who were pretreated with 10 mg. of mercaptoimidazol per day for 3 days, thyroidal 'I uptake rate were examined on 3 and 4 hr after 127I and "'I dose without perchlorate administration. The mean 3 and 4 hr uptake rates were 3.70+0.49 and 3.85+0.62%, respectively. 5) In 6 subjects pretreated with mercaptoimidazol (10 mg. for 3 days). Doses of 0.5 mg. of carrier "'I were given by mouth with "'I, there was a positive discharge of "'I from thyroids. The 131I discharge value was 38.68+6.86%. In japanese persons, the daily excretion of iodide in urine generally amounted to 0.5 to 5.0 mg. and less than 0.5 mg. in subjects who were taking an iodine restricted diet. It did not seem that the administration of 0.5 mg. of carrier 'I caused in normal subjects an acute inhibitory effect on organic binding of iodide in the thyroid. Perchlorate discharge tests carried out in subjects pretreated with a small dose of mercaptoimidazol for 3 days. The tests by customary methods were negative. But, a significant positive discharge of "'I was observed when they were administrated with 0.5 mg. of carrier "'I and 'I tracer

A Modified Perchlorate Discharge Test for Detection of the Partial Defect of Iodide Organification in Thyroid