Open AccessControl of solvated crystallisation of α-lactose monohydrate
Author(s) -
Amira Rachah,
Dominikus Noll,
Fabienne Espitalier,
Fabien Baillon
Publication year - 2015
Publication title -
international journal of mathematical modelling and numerical optimisation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.195
H-Index - 12
eISSN - 2040-3615
pISSN - 2040-3607
DOI - 10.1504/ijmmno.2015.069968
Subject(s) - crystallization , lactose , privilege (computing) , crystal (programming language) , materials science , crystallography , process engineering , chemical engineering , computer science , thermodynamics , chemistry , physics , food science , computer security , engineering , programming language
International audienceWe present a mathematical model of solvated crystallization of α-lactose monohydrate and discuss strategies to control the crystallization process in semi-batch mode with the goal to privilege the production of small particles in the range between 130 µm and 330 µm. We compare specific and unspecific cost functions leading to optimal strategies with significantly different effects on product quality. Control inputs are temperature, feed rate, and the choice of an appropriate crystal seed
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